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Improved thermospray accurate mass measurement using a magnetic sector instrument
Author(s) -
Davidson W. C.,
Dinallo R. M.,
Hansen G. E.
Publication year - 1991
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200200610
Subject(s) - vaporizer , thermospray , materials science , analytical chemistry (journal) , magnetic field , body orifice , sensitivity (control systems) , mass spectrometry , chemistry , physics , electronic engineering , chromatography , engineering , mechanical engineering , quantum mechanics , tandem mass spectrometry , selected reaction monitoring , waste management
A method permitting accurate mass measurement of full‐scan thermospray mass spectra is presented. Improved resolution and sensitivity were achieved by the addition of source cryopumping. Ion beam stability was enhanced by adaptation of a vaporizer tip with a sapphire orifice. Large systematic errors, such as previously reported with current‐controlled scanning and widely spaced reference ions, were greatly reduced by employing field‐controlled magnetic scanning. The method permits measurements accurate to better than 10 ppm while employing a simple polyethylene glycol standard.