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The characterization of synthetic by‐products by B / E linked scanning and high‐resolution thermospray mass spectrometry
Author(s) -
Dinallo R. M.,
Davidson W. C.,
Hansen G. E.
Publication year - 1991
Publication title -
biological mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1052-9306
DOI - 10.1002/bms.1200200506
Subject(s) - thermospray , mass spectrometry , characterization (materials science) , resolution (logic) , impurity , chemistry , chromatography , high resolution , analytical chemistry (journal) , tandem mass spectrometry , materials science , selected reaction monitoring , remote sensing , organic chemistry , geology , nanotechnology , artificial intelligence , computer science
Characterization of unknown synthetic by‐products from a test synthesis of the experimental inhibitor of HIV‐1 reverse transcriptase, BI‐RG‐587, is presented. Seven impurities were separated and characterized by thermospray liquid chromatography/mass spectrometry using low‐resolution, high‐resolution, and B / E linked scanning methods. The high‐resolution mass measurements which were obtained were accurate to within 10 ppm of structures proposed for synthetic by‐products present at the 0.1% level. Linked scans produced daughter ion spectra for each impurity to further aid in the characterization.