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The metabolism of trimipramine in the rat
Author(s) -
Coutts R. T.,
Hussain M. Saleh,
Micetich R. G.,
Daneshtalab M.,
Baker G. B.
Publication year - 1990
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200191303
Subject(s) - derivatization , alicyclic compound , chemistry , chromatography , metabolism , hydrolysis , azepine , gas chromatography–mass spectrometry , acetylation , urine , organic chemistry , biochemistry , mass spectrometry , gene
Studies on the metabolism of the tricyclic antidepressant trimipramine, 5‐(3‐dimethylamino‐2‐methylpropyl)‐10, 11‐dihydro‐5 H ‐dibenz[ b , f ] azepine, in the rat are described. Many metabolites of trimipramine (TMP) were isolated from rat urine after enzymatic hydrolysis and their structures were identified by a gas chromatographic/mass spectrometric method, before and after appropriate chemical derivatization. Besides unchanged TMP, 20 metabolites were characterized (underivatized, and after acetylation), of which 12 had undergone alicyclic (C 10 or C 11 ) oxidation. This is a hitherto unreported metabolic pathway for TMP in the rat.