The metabolism of trimipramine in the rat | Zendy

Coutts R. T. | Zendy; Hussain M. Saleh | Zendy; Micetich R. G. | Zendy; Daneshtalab M. | Zendy; Baker G. B. | Zendy

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The metabolism of trimipramine in the rat

Author(s) -

Coutts R. T.,

Hussain M. Saleh,

Micetich R. G.,

Daneshtalab M.,

Baker G. B.

Publication year - 1990

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200191303

Subject(s) - derivatization , alicyclic compound , chemistry , chromatography , metabolism , hydrolysis , azepine , gas chromatography–mass spectrometry , acetylation , urine , organic chemistry , biochemistry , mass spectrometry , gene

Studies on the metabolism of the tricyclic antidepressant trimipramine, 5‐(3‐dimethylamino‐2‐methylpropyl)‐10, 11‐dihydro‐5 H ‐dibenz[ b , f ] azepine, in the rat are described. Many metabolites of trimipramine (TMP) were isolated from rat urine after enzymatic hydrolysis and their structures were identified by a gas chromatographic/mass spectrometric method, before and after appropriate chemical derivatization. Besides unchanged TMP, 20 metabolites were characterized (underivatized, and after acetylation), of which 12 had undergone alicyclic (C 10 or C 11 ) oxidation. This is a hitherto unreported metabolic pathway for TMP in the rat.

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