Premium
Fast atom bombardment mass spectral analyses of Photofrin II ® and its synthetic analogs
Author(s) -
Pandey Ravindra K.,
Siegel Marshall M.,
Tsao Rushung,
McReynolds James H.,
Dougherty Thomas J.
Publication year - 1990
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200190705
Subject(s) - porphyrin , chemistry , ether , derivative (finance) , mass spectrometry , spectroscopy , fast atom bombardment , photochemistry , covalent bond , mass spectrum , medicinal chemistry , stereochemistry , organic chemistry , physics , chromatography , quantum mechanics , financial economics , economics
Fast atom bombardment (FAB) mass spectroscopy was used to characterize the components of Photofrin II ® . The data indicate that the oligomeric components of Photofrin II ® contain up to nine porphyrin units. In order to elucidate the nature of covalent linkages between porphyrin units, Photofrin II ® methyl ester and a porphyrin derivative‐2 (2A) were synthesized and characterized by FAB mass spectroscopy. Model studies were also performed by analyzing possible components of Photofrin II ® , namely, porphyrin dimers 3, 4, 5, 6 and trimer 7 with ether or ester linkages. The higher porphyrin oligomers joined by only ether linkages were also synthesized and characterized by FAB mass spectroscopy. The model studies indicate that the porphyrin units in Photofrin II ® are linked with ether or ether/ester linkages.