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Diurnal rhythm in the plasma concentration of cortisol in paediatric patients with orthostatic dysregulation
Author(s) -
Shibasaki Hiromi,
Furuta Takashi,
Kasuya Yasuji,
Okabe Toshinari,
Katoh Takashi,
Kogo Toshiaki,
Hirayama Tsuneo
Publication year - 1990
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200190404
Subject(s) - orthostatic vital signs , endocrinology , medicine , circadian rhythm , cortisol awakening response , hydrocortisone , blood pressure
A gas chromatographic/mass spectrometric method using stable isotopically labelled cortisol as an internal standard was employed to determine patterns of episodic secretion of cortisol in three normal subjects and four paediatric patients with orthostatic dysregulation. The measurement of the plasma cortisol level at frequent time intervals revealed how the daily secretory pattern of cortisol differs in these patients and normal subjects.