Gas chromatography/negative chemical ionization mass spectrometry of intact glucuronides | Zendy

Brown Sharon Y. | Zendy; Garland William A. | Zendy; Fukuda Elaine K. | Zendy

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Gas chromatography/negative chemical ionization mass spectrometry of intact glucuronides

Author(s) -

Brown Sharon Y.,

Garland William A.,

Fukuda Elaine K.

Publication year - 1990

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200190105

Subject(s) - chemistry , chemical ionization , mass spectrometry , chromatography , gas chromatography , gas chromatography–mass spectrometry , bromide , fast atom bombardment , direct electron ionization liquid chromatography–mass spectrometry interface , glucuronide , ionization , ion , organic chemistry , metabolite , biochemistry

Gas chromatography‐negative chemical ionization mass spectrometry (GC–NCIMS) has been applied to the analysis of O ‐ and S ‐glucuronides. The glucuronides were derivatized with pentafluorobenzyl (PFB) bromide and Tri‐Sil, and analyzed by GC–NCIMS. All glucuronides gave a large [M—PFB] − ion indicative of the molecular weight of the compound. This methodology has been successfully applied to the identification of a glucuronide of unknown structure.

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