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Isotope dilution assay for urinary methanesulfinic and methanesulfonic acids: Application to detection of methylthio turnover
Author(s) -
Bakke J. E.,
Feil V. J.,
Zaylskie R. G.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200181210
Subject(s) - methanesulfonic acid , urine , excretion , isotope dilution , chemistry , metabolism , urinary system , dilution , chromatography , endocrinology , medicine , biochemistry , biology , organic chemistry , mass spectrometry , physics , thermodynamics
Methanesulfinic and methanesulfonic acids were shown to be present in urine from rats fed laboratory rat diet. The daily excretions of each acid were equivalent at 0.47 μmol day −1 . The excretion of methanesulfinic acid increased about ninefold and that of methanesulfonic doubled when rats were dosed with 17 μmol of pentachlorothioanisole. The excretion of methanesulfinic acid above control levels in urine may be a method for detecting methylthio displacements that occur during the intermediary metabolism of xenobiotics.