Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry | Zendy

Davis Preston P. | Zendy; Choma Nadia | Zendy; Crews Theodore | Zendy; Fukuda Elaine K. | Zendy

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Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry

Author(s) -

Davis Preston P.,

Choma Nadia,

Crews Theodore,

Fukuda Elaine K.

Publication year - 1989

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200181105

Subject(s) - chemistry , chromatography , mass spectrometry , isotope dilution , hexane , extraction (chemistry) , gas chromatography , chemical ionization , gas chromatography–mass spectrometry , ammonia , analytical chemistry (journal) , ionization , ion , organic chemistry

A gas chromatographic/mass spectrometric procedure has been developed for the quantification of a diltiazem analog, naltiazem, in human plasma. The assay utilizes an extraction at neutral pH with hexane:ethylene dichloride:methyl‐ t ‐butyl ether (70:20:10), selective ion monitoring, methane or ammonia positive chemical ionization mass spectrometry and stable isotope dilution. The method has been used to analyze plasma concentrations of naltiazem in clinical samples over a range of 2–200 ng ml −1 , using 1 ml of plasma.

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