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Quantitative determination of naltiazem in human plasma by gas chromatography/mass spectrometry
Author(s) -
Davis Preston P.,
Choma Nadia,
Crews Theodore,
Fukuda Elaine K.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200181105
Subject(s) - chemistry , chromatography , mass spectrometry , isotope dilution , hexane , extraction (chemistry) , gas chromatography , chemical ionization , gas chromatography–mass spectrometry , ammonia , analytical chemistry (journal) , ionization , ion , organic chemistry
A gas chromatographic/mass spectrometric procedure has been developed for the quantification of a diltiazem analog, naltiazem, in human plasma. The assay utilizes an extraction at neutral pH with hexane:ethylene dichloride:methyl‐ t ‐butyl ether (70:20:10), selective ion monitoring, methane or ammonia positive chemical ionization mass spectrometry and stable isotope dilution. The method has been used to analyze plasma concentrations of naltiazem in clinical samples over a range of 2–200 ng ml −1 , using 1 ml of plasma.