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Mass spectrometric approaches in structural characterization of cephalosporins
Author(s) -
Scandola M.,
Tarzia G.,
Gaviraghi G.,
Chiarello D.,
Traldi P.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200181002
Subject(s) - fast atom bombardment , mass spectrometry , ion , chemistry , electron ionization , ionization , vaporization , soft laser desorption , kinetic energy , metastability , reflectron , analytical chemistry (journal) , desorption , matrix assisted laser desorption/ionization , time of flight mass spectrometry , chromatography , physics , organic chemistry , adsorption , quantum mechanics
The mass spectrometric behaviour of five structurally different cephalosporins has been studied in detail by means of different ionization/desorption methods (electron impact, fast atom bombardment, desorption chemical ionization, laser‐induced vaporization) and metastable ion studies (linked scans and mass‐analysed ion kinetic energy spectrometry). The best results were obtained by fast atom bombardment mass spectrometry, leading to both molecular ions and fragment ions diagnostic for structural identification.