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Parent ion spectroscopy in the identification of advanced glycation products
Author(s) -
Lapolla A.,
Poli T.,
Gerhardinger C.,
Fedele D.,
Crepaldi G.,
Chiarello D.,
Ghezzo E.,
Traldi P.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180911
Subject(s) - glycation , chemistry , spectroscopy , imidazole , mass spectrometry , ion , polylysine , chromatography , organic chemistry , biochemistry , physics , receptor , quantum mechanics
Advanced glycation products have been investigated by parent ion spectroscopy, employing B 2 / E = constant linked scans of furoyl ions obtained from hydrolysed glycated albumin and polylysine mixtures, without any extraction procedures. Using such an instrumental approach, together with exact mass measurements and collision spectroscopy, the identification of 2‐(2‐furoyl)‐4‐hydroxyl‐1 H ‐imidazole and 2‐(2‐furoyl)‐4‐carboxy‐1 H ‐imidazole among the advanced glycation products has been achieved.