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Ultrastructural localization of aluminium in liver of aluminium maltol‐treated rabbits by laser microprobe mass analysis
Author(s) -
Vandeputte D.,
Van Grieken R. E.,
Jacob W. A.,
Savory J.,
Bertholf R. L.,
Wills M. R.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180815
Subject(s) - aluminium , microprobe , ultrastructure , toxicity , electron microprobe , pathology , chemistry , metallurgy , materials science , mineralogy , medicine , organic chemistry
By means of laser microprobe mass analysis (LAMMA), we have studied the ultrastructural localization of aluminium in livers of aluminium maltol‐treated rabbits. This animal model was developed to study long‐term aluminium toxicity using systemic (intravenous) administration of aluminium. We could only detect aluminium in electron‐dense inclusion bodies found in large, sometimes multinucleated cells. These results prove that the actual observation of aluminium deposits in liver with LAMMA gives more information than bulk analysis and can be very useful to explore mechanisms of toxicity.