Premium
Analysis of 18 O enrichment in biological fluids by continuous flow–isotope ratio mass spectrometry
Author(s) -
McMillan D. C.,
Preston T.,
Taggart D. P.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180805
Subject(s) - isotope ratio mass spectrometry , isotope , mass spectrometry , stable isotope ratio , chemistry , continuous flow , isotope analysis , instrumentation (computer programming) , chromatography , analytical chemistry (journal) , biochemical engineering , computer science , geology , engineering , physics , quantum mechanics , operating system , oceanography
A novel method is described for the analysis of 18 O in urine by continuous flow‐isotope ratio mass spectrometry (CF–IRMS), after sample equilibration with CO 2 . The method is shown to be fast, precise and accurate and therefore facilitates studies of total body water and water turnover in the clinical field. The method uses existing CF–IRMS instrumentation with minor hardware modification which does not compromise routine analysis of 13 C and 15 N. This method emphasizes the versatility of CF–IRMS and thus its economy for the biomedical research group using stable isotope tracers.