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High‐sensitivity thermospray ionization mass spectrometry of dyes
Author(s) -
Yi Jehuda,
Jones Tammy L.,
Betowski Leon D.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180614
Subject(s) - thermospray , mass spectrometry , ionization , chemistry , mass spectrum , fast atom bombardment , analytical chemistry (journal) , chemical ionization , ion , chromatography , organic chemistry , tandem mass spectrometry , selected reaction monitoring
A series of dyes belonging to different chemical classes have been analyzed by thermospray (TSP) ionization mass spectrometry using a modified source containing a wire‐repeller. Detection limits were determined and found to be in the range 0.05–20 ng, which are lower by a factor of 10–400 than previously published results. Positive‐ion TSP mass spectra of some sulfonated dyes could be recorded for the first time owing to the increased sensitivity. Losses of SO 3 Na and 2SO 3 Na as well as losses of Na and 2Na were observed. The losses of each one of these groups involved replacement by a hydrogen atom.