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Laser‐induced vaporization mass spectrometry of rifamycins
Author(s) -
Bravo P.,
Cavalleri B.,
Zerilli L. F.,
Maccioni A. M.,
Traldi P.,
Cecchetti W.,
Polloni R.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180504
Subject(s) - mass spectrometry , ionization , mass spectrum , chemistry , electron ionization , ion , vaporization , analytical chemistry (journal) , ionic bonding , laser , chemical ionization , atmospheric pressure laser ionization , thermal ionization , thermal decomposition , chromatography , optics , organic chemistry , physics
The mass spectra of many rifamycins cannot be obtained by electron ionization (EI) owing to their thermal decomposition. When a laser beam is used to vaporize the sample through an optic fibre inserted in a hollow probe which reaches the sample cup, decomposition is minimized and the EI spectra show abundant molecular ions and fragments of structurally high diagnostic value. These ionic species are easily observed owing to the lack of chemical noise often present in soft ionization methods, such as direct liquid chemical ionization and fast atom bombardment.