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Fast atom bombardment mass spectra of peptides. Dimer ion studies. Part VI
Author(s) -
Jankowski K.,
Virelizier H.,
Gaudin D.,
Tabet J.C.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180502
Subject(s) - dimer , chemistry , ion , mass spectrum , fast atom bombardment , dissociation (chemistry) , crystallography , stereochemistry , enkephalin , pyridine , medicinal chemistry , opioid , biochemistry , organic chemistry , receptor
Positive ion fast atom bombardment mass spectra of the opioid pentapeptides leucine enkephalin (1) (H‐Tyr‐Gly‐Gly‐Phe‐Leu‐OH or YGGFL), methionine enkephalin (2) (H‐Tyr‐Gly‐Gly‐Phe‐Met‐OH or YGGFM) and leucine enkephalin‐ 2 H 2 (3) (H‐Tyr‐ 2 Gly‐ 2 H 2 ‐Gly‐Phe‐Leu‐OH or YGGFL‐ 2 H 2 ) have been recorded in glycerol. The following experiments have been carried out: (i) dimer studies [2M + 1] + ; (ii) decompositions of dimers: daughter ions from (YGGFL) 2 , (YGGFL‐YGGFL‐ 2 H 2 ) and (YGGFL‐ 2 H 2 ) 2 as well as (YGGFM–YGGFL) and (YGGFM) 2 dimers; (iii) solvation site and pyridine collision‐activated dissociation studies for dimer ions; (iv) mechanism of formation of [(2M + 1) – Gly 4 ] + ions.