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High‐performance liquid chromatographic/mass spectrometric and high‐performance liquid chromatographic/tandem mass spectrometric analysis of carbamate pesticides
Author(s) -
Chiu Kin S.,
Van Langenhove Agnes,
Tanaka Calvin
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180309
Subject(s) - chemistry , thermospray , chromatography , mass spectrometry , triple quadrupole mass spectrometer , tandem mass spectrometry , selected reaction monitoring , analytical chemistry (journal) , carbamate , ammonium acetate , high performance liquid chromatography , organic chemistry
The thermospray ionization mass spectra of selected carbamate pesticides were obtained using both single‐stage and triple‐stage quadrupole mass spectrometry in conjunction with high‐performance liquid chromatography. With the use of the single‐quadrupole mass spectrometer and ammonium acetate as the mobile phase, enhanced sensitivity for the analytes of interest was obtained by monitoring the relatively intact [M + 1] + or [M + 18] + adduct ions. Further structural characterization of the carbamates was not readily obtainable owing to the lack of diagnostic bond cleavages. The single‐stage quadrupole analyses were therefore complemented by triple‐stage quadrupole analyses. Here, collisionally activated daughter ion spectra exhibited structure‐specific fragmentations. In addition, the enhanced selectivity and specificity provided by tandem mass spectrometry allowed use of the technique as a rapid screening tool for carbamates without the need for the chromatographic separation step.