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Packed capillary liquid chromatography/mass spectrometry using a moving belt interface
Author(s) -
Barefoot A. C.,
Reiser R. W.
Publication year - 1989
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200180111
Subject(s) - chromatography , capillary action , mass spectrometry , chemistry , packed bed , polar , analytical chemistry (journal) , materials science , composite material , physics , astronomy
Packed capillary liquid chromatography/mass spectrometry using a moving belt interface is a practical, versatile technique for the identification of unknowns. The low flow rates (1–2 μl min −1 ) improve the operation of the moving belt and allow direct deposition of eluates from reversed‐phase liquid chromatographic columns containing large proportions of water. Column performance and durability is equivalent to that obtained with conventional or microbore liquid chromatographic columns. Techniques have been developed for analyzing dilute solutions with no loss in column performance and for the detection of radiolabeled metabolites. Applications to analyses of polar, thermally labile compounds and environmental samples are presented.