Premium
Sequence effect on the slow degradations of dinucleotides by fast atom bombardment tandem mass spectrometry 1
Author(s) -
Liguori Angelo,
Sindona Giovanni,
Uccella Nicola
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160189
Subject(s) - fast atom bombardment , tandem , sequence (biology) , chemistry , atom (system on chip) , biophysics , computational biology , biology , mass spectrometry , biochemistry , materials science , computer science , parallel computing , chromatography , composite material
The mass‐analysed ion kinetic energy spectrum of isomeric dinucleotides having dTpdU and dUpdT structure is characterized by the preferred elimination of the pyrimidine base linked to the 5′ end deoxyribose unit. Similar results have been obtained with differently substituted dimers such as dCpdT and DMTdTp(S)dU. The observed selectivity in the glycosidic bond dissociation provides a straightforward criterion for the sequencing of the sampled species.