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Tandem mass spectrometric studies of the fragmentation of penicillins and their metabolites
Author(s) -
Suwanrumpha Somchai,
Flory Donald A.,
Freas Royal B.,
Vestal Marvin L.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160175
Subject(s) - chemistry , fragmentation (computing) , mass spectrometry , tandem mass spectrometry , collision induced dissociation , thermospray , mass spectrum , fast atom bombardment , chromatography , dissociation (chemistry) , protein mass spectrometry , tandem , analytical chemistry (journal) , selected reaction monitoring , organic chemistry , computer science , operating system , materials science , composite material
The fragmentation of two penicillins, ampicillin and amoxicillin, and their principal metabolites has been studied by a combination of liquid chromatography/thermospray mass spectrometry and tandem mass spectrometry. A high‐resolution tandem mass spectrometer was used to obtain chemical ionization, fast‐atom bombardment, and collision‐induced dissociation mass spectra. Structural information and fragmentation mechanisms have been deduced from ions in the mass and collision spectra. This knowledge is useful in the analysis and identification of metabolites of ampicillin and related drugs in human body fluids.