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Potential of inductively coupled plasma mass spectrometry for trace element metabolism studies in man
Author(s) -
Dalgarno B. G.,
Brown R. M.,
Pickford C. J.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160174
Subject(s) - isotope , inductively coupled plasma mass spectrometry , strontium , chemistry , trace element , isotopes of strontium , mass spectrometry , urine , chromatography , stable isotope ratio , detection limit , analytical chemistry (journal) , radiochemistry , environmental chemistry , physics , biochemistry , organic chemistry , quantum mechanics
A new inorganic mass spectrometric technique is described which allows sensitive, rapid and economic determination of trace element concentrations and isotope ratios in aqueous samples. This paper illustrates the potential of the technique in one particular application area, namely the measurement of strontium isotope ratios in human blood and urine following ingestion of an enriched stable strontium isotope. The data from a human volunteer experiment illustrate the viability of the analytical method, with measurement precisions of ± 0.2% (1σ) achieved for the isotope ratio in urine samples, which contained approximately 300 ng 86 Sr in the volume required for analysis. Measurement precision is limited by counting statistics.