Premium
Morphogens from Dictyostelium discoideum
Author(s) -
Masento Mark S.,
Morris Howard R.,
Taylor Graham W.,
Kay Robert R.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160169
Subject(s) - dictyostelium discoideum , chemistry , morphogen , ketone , bioassay , mass spectrometry , stereochemistry , biochemistry , chromatography , organic chemistry , ecology , biology , gene
The morphogen, DIF‐1, from Dictyostelium discoideum has recently been characterized as 1‐(3,5‐dichloro‐2,6‐dihydroxy‐4‐methoxyphenyl)‐1‐hexanone. Two related differentiation‐inducing factors, DIF‐2 and DIF‐3, have been identified as the butyl ketone and monochloro analogues of DIF‐1, respectively. These substances together with a number of structural analogues have been synthesized and subsequently analysed by mass spectrometry and bioassay.