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Applications of thermospray liquid chromatography/mass spectrometry
Author(s) -
Baczynskyj L.,
Bronson G. E.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160147
Subject(s) - thermospray , mass spectrometry , chromatography , chemistry , analytical chemistry (journal) , mass spectrum , resolution (logic) , high performance liquid chromatography , liquid chromatography–mass spectrometry , tandem mass spectrometry , selected reaction monitoring , artificial intelligence , computer science
Thermospray liquid chromatography/mass spectrometry using a double‐focusing magnetic sector mass spectrometer has been studied. The quality of the thermospray mass spectra were often a function of the solvent mixture used, and use of gradients affected the quality of some thermospray mass spectra. High resolution mass measurements using peak matching gave excellent results for pure compounds and mixtures which did not have 13 C isotope interferences. When 13 C isotope interference was a problem high‐performance liquid chromatographic separation together with magnetic scanning was used.