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Isomer‐specific determination of 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin and related compounds in human fat and food
Author(s) -
Beck H.,
Eckart K.,
Mathar W.,
Rühl Ch.S.,
Wittkowski R.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160128
Subject(s) - tetrachlorodibenzo p dioxin , chemistry , environmental chemistry , food science , chromatography , organic chemistry , toxicity
An analytical procedure for the isomer‐specific quantification of polychlorinated dibenzo‐ p ‐dioxins and dibenzofurans in samples of human and animal origin is described. It consists of a large‐scale clean‐up including various kinds of column chromatography and high‐resolution gas chromatographic/mass spectrometric quantification referring to internal 13 C‐labelled standards. By additional application of gel‐permeation chromatography and the use of a retention gap, detection limits in the low ppq range (10 −15 ) were achieved.