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Structural characterization of drugs and oxygenated metabolites by laser microprobe mass spectrometry (LAMMA)
Author(s) -
Van Vaeck L.,
Van Espen P.,
Gijbels R.,
Lauwers W.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200160121
Subject(s) - fragmentation (computing) , chemistry , microprobe , mass spectrometry , ion , desorption , electron microprobe , yield (engineering) , mass spectrum , laser , analytical chemistry (journal) , chromatography , materials science , organic chemistry , adsorption , mineralogy , physics , computer science , optics , metallurgy , operating system
Laser microprobe mass analysis (LAMMA) was used for the structural characterization of polyfunctional drugs and their oxygenated metabolites, in particular the N ‐oxides. The spectra usually yield the molecular weight as well as intense fragments. The structural information is characteristically distributed between the positive and negative ions. To rationalize the unfamiliar fragmentation, tentative pathways are introduced. Key elements are the formation of odd‐electron molecular (and fragment) ions, the correlation between cations and anions, as well as the three‐dimensional representation of structures. The combination of mild desorption and abundant fragmentation makes LAMMA a valuable tool in the study of N ‐oxides.