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Laser desorption/Fourier transform mass spectrometry of steroids
Author(s) -
Fung Eric T.,
Wilkins Charles L.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200151106
Subject(s) - fourier transform ion cyclotron resonance , mass spectrometry , mass spectrum , chemistry , ion , analytical chemistry (journal) , fragmentation (computing) , electron ionization , ionization , chromatography , organic chemistry , computer science , operating system
Mass spectra of six representative underivatized steroids and three parent hydrocarbons were obtained using laser desorption/Fourier transform (LD/FT) mass spectrometry. The carbonyl steroids, with the exception of aldosterone, yielded abundant [M + H] + ions. For cholesterol, a major fragment ion was that corresponding to dehydration. The hydrocarbons produced [M + H] + , M + and [M − H] + ions, in addition to expected alkyl cleavage ions including those resulting from methyl loss. The LD/FT mass spectra of all were qualitatively similar to electron ionization spectra, but showed somewhat less fragmentation.