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Negative ion mass spectra of dihydropyridine calcium‐channel blockers
Author(s) -
Ehrhardt J. D.,
Ziegler J. M.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200151003
Subject(s) - dihydropyridine , nifedipine , chemistry , nitro , fragmentation (computing) , mass spectrum , ion , calcium channel , ring (chemistry) , spectral line , stereochemistry , medicinal chemistry , calcium , physics , organic chemistry , alkyl , astronomy , computer science , operating system
Abstract The negative ion mass spectra of some dihydropyridine analogues of nifedipine are studied; they show a fragmentation which is highly dependent on the position of the nitro group on the phenyl ring: 3′‐nitro derivatives give essentially the molecular anion, whereas 2′‐nitro derivatives lose successively H 2 O, RO and O. In addition, (2,1,3‐benzoxadiazol‐4‐yl) derivatives show essentially a [MROH] − peak. Possible pathways for these fragmentations are given.