The enzymatic and mass spectrometric identification of 2‐oxophytanic acid, a product of the peroxisomal oxidation of  L ‐2‐hydroxyphytanic acid | Zendy

Vamecq Joseph | Zendy; Draye JeanPierre | Zendy

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The enzymatic and mass spectrometric identification of 2‐oxophytanic acid, a product of the peroxisomal oxidation of L ‐2‐hydroxyphytanic acid

Author(s) -

Vamecq Joseph,

Draye JeanPierre

Publication year - 1988

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200150607

Subject(s) - phytanic acid , peroxisome , chemistry , metabolite , biochemistry , enzyme , mass spectrometry , oxidase test , beta oxidation , chromatography , gene

A previously unreported metabolite of the mammalian phytanic acid breakdown pathway, 2‐oxophytanic acid, was isolated and analysed by mass spectrometry. The metabolic origin of the 2‐oxoacid is the oxidation by a rat kidney peroxisomal H 2 O 2 ‐generating oxidase of L ‐2‐hydroxyphytanic acid, a well‐established intermediate in phytanic acid α‐oxidation.

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