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The enzymatic and mass spectrometric identification of 2‐oxophytanic acid, a product of the peroxisomal oxidation of L ‐2‐hydroxyphytanic acid
Author(s) -
Vamecq Joseph,
Draye JeanPierre
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150607
Subject(s) - phytanic acid , peroxisome , chemistry , metabolite , biochemistry , enzyme , mass spectrometry , oxidase test , beta oxidation , chromatography , gene
A previously unreported metabolite of the mammalian phytanic acid breakdown pathway, 2‐oxophytanic acid, was isolated and analysed by mass spectrometry. The metabolic origin of the 2‐oxoacid is the oxidation by a rat kidney peroxisomal H 2 O 2 ‐generating oxidase of L ‐2‐hydroxyphytanic acid, a well‐established intermediate in phytanic acid α‐oxidation.