Laser desorption/fourier transform ion cyclotron resonance mass spectrometry: Digoxin, digitoxin, and their reduced and sugar‐hydrolyzed metabolites | Zendy

Shomo Ronald E. | Zendy; Chandrasekaran Appavu | Zendy; Marshall Alan G. | Zendy; Reuning Richard H. | Zendy; Robertson Larry W. | Zendy

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Laser desorption/fourier transform ion cyclotron resonance mass spectrometry: Digoxin, digitoxin, and their reduced and sugar‐hydrolyzed metabolites

Author(s) -

Shomo Ronald E.,

Chandrasekaran Appavu,

Marshall Alan G.,

Reuning Richard H.,

Robertson Larry W.

Publication year - 1988

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200150510

Subject(s) - fourier transform ion cyclotron resonance , digitoxin , chemistry , mass spectrometry , analytical chemistry (journal) , mass spectrum , ion , digoxin , ion cyclotron resonance , ion source , chromatography , cyclotron , heart failure , medicine , organic chemistry

Mass spectra of digoxin and digitoxin (the most widely prescribed drugs for treatment of congestive heart failure) and a complete set of their 14 dihydro‐ and sugar‐hydrolyzed metabolites have been obtained via laser desorption/ionization with a Fourier transform ion cyclotron resonance (LD/FT/ICR) mass spectrometer. The most intense peak is typically the pseudomolecular [M + K] + ion, but fragment ions corresponding to loss of 1‐‐3 sugars and hydroxyls are also observed. LD/FT/ICR mass spectra for all 16 compounds were produced with a single set of sample and spectrometer parameters. No matrix peaks are present. Finally, LD/FT/ICR provides dynamic mass accuracy within ≈5 ppm throughout a mass range of 404 < m / z < 819.

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