Synthesis of deuterium‐labelled elliptinium and its use in metabolic studies | Zendy

Gouyette Alain | Zendy

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Synthesis of deuterium‐labelled elliptinium and its use in metabolic studies

Author(s) -

Gouyette Alain

Publication year - 1988

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200150502

Subject(s) - deuterium , chemistry , radiochemistry , nuclear physics , physics

The 9‐hydroxy‐2‐(U‐ 2 H 3 ) methylellipticinium acetate (elliptinium) was synthesized with an isotopic purity of at least 96%. The structure was confirmed by proton nuclear magnetic resonance and direct probe fast atom bombardment mass spectrometry. A mixture of elliptinium and its deuterated analogue was administered intravenously to rats. In urine, after analysis by liquid chromatography/mass spectrometry (LC/MS), unchanged drug and N ‐acetylcysteinylelliptinium were found. In bile, after ion‐pair extraction and LC/MS, the glutathionyl‐elliptinium was found in addition to the parent drug and the N ‐acetylcysteine adduct.

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