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Identification of metabolites of tiropramide in human urine
Author(s) -
Arigoni R.,
Chistè R.,
Makovec F.,
Setnikar I.,
Benfenati E.,
Fanelli R.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150404
Subject(s) - urine , chromatography , mass spectrum , mass spectrometry , hydrochloride , gas chromatography–mass spectrometry , chemistry , gas chromatography , identification (biology) , biology , organic chemistry , biochemistry , botany
The metabolites of tiropramide were extracted from the urine of healthy volunteers given tiropramide hydrochloride orally. Eight metabolites of tiropramide were found by gas chromatography/mass spectrometry. Three were identified on the basis of their mass spectra, retention times and comparison with synthetic standards. For the others a probable structure is proposed on the basis of their mass spectra.