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Negative ion chemical ionization gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of prostanoid pentafluorobenzyl ester/methoxime/trimethylsilyl ether derivatives
Author(s) -
Schweer Horst,
Seyberth Hannsjörg W.,
Meese Claus O.,
Fürst Otto
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150305
Subject(s) - chemistry , trimethylsilyl , chemical ionization , mass spectrometry , ether , gas chromatography , chromatography , mass spectrum , gas chromatography–mass spectrometry , ion , ionization , organic chemistry
Negative ion chemical ionization mass spectra of prostaglandin F 2α , prostaglandin E 2 , prostaglandin D 2 , 6‐oxo‐prostaglandin F 1α , 2,3‐dinor‐6‐oxo‐prostaglandin F 1α , thromboxane B 2 , 2,3‐dinor‐thromboxane B 2 , and 11‐dehydro‐thromboxane B 2 pentafluorobenzyl ester (PFB)/methoxime/trimethylsilyl ether derivatives are presented. Collisionally activated decomposition mass spectra of the [M – PFB] − ions at collision energies of 8–24 eV and argon collision gas pressures of 1–2 mTorr almost show only fragmentation of trimethylsilanol, (CH 3 ) 2 SiCHOH, (CH 3 ) 2 SiCH 2 and methanol whereas, except for carbon dioxide loss, only few low‐intensity fragments from the carbon skeleton of the prostanoids are observed.