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Gas chromatography/mass spectrometry and gas chromatography/tandem mass spectrometry of methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandins
Author(s) -
Schweer Horst,
Seyberth Hannsjörg W.,
Meese Claus O.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150303
Subject(s) - chemistry , trimethylsilyl , ether , mass spectrometry , mass spectrum , chromatography , gas chromatography , prostaglandin , gas chromatography–mass spectrometry , tandem mass spectrometry , organic chemistry , biochemistry
Electron impact mass spectra of methyl ester/trimethylsilyl ether derivatives of prostaglandin F 2α and methyl ester/methoxime/trimethylsilyl ether derivatives of prostaglandin E 2 , prostaglandin D 2 , 6‐oxo‐prostaglandin F 1α and 2,3‐dinor‐6‐oxo‐prostaglandin F 1α are presented. Most of the prostaglandins studied have additionally been 2 H‐labelled at different sites in order to assign the corresponding fragment ions. Collisionally activated decomposition mass spectra of the most intense parent ions in the high‐mass region were taken. High‐intensity, prostaglandin‐characteristic daughter fragments will allow a reliable quantification of prostaglandins in biological fluids and a reduction of sample clean‐up.