Premium
A gas chromatographic/mass spectrometric screening, confirmation, and quantification method for estrogenic compounds
Author(s) -
Covey Thomas R.,
Silvestre Dominique,
Hoffman Michael K.,
Henion Jack D.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150107
Subject(s) - chromatography , hexestrol , zeranol , chemistry , mass spectrometry , estriol , extraction (chemistry) , diethylstilbestrol , gas chromatography–mass spectrometry , gas chromatography , solid phase extraction , detection limit , selected ion monitoring , sample preparation , biochemistry , medicine , hormone
A method is described for the screening, quantification and confirmation of a variety of estronenic substances in animal tissues. A solid‐phase extraction technique combined with a liquid/liquid extraction allows for rapid sample preparation and high throughput for the following compounds in bovine liver, muscle and kidney: diethylstilbestrol, dienestrol, hexestrol, zeranol, taleranol, zearalanone, zearalenone, zearalenol, estradiol and estriol. Gas chromatography/mass spectrometry and selected ion monitoring is used for the determination with detection limits ranging from 50 to 150 ppt.