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Chemical modification in mass spectrometry IV—2‐alkenyl‐4,4‐dimethyloxazolines as derivatives for the double bond location of long‐chain olefinic acids
Author(s) -
Zhang J. Y.,
Yu Q. T.,
Liu B. N.,
Huang Z. H.
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150106
Subject(s) - double bond , mass spectrometry , chemistry , chain (unit) , organic chemistry , stereochemistry , computational chemistry , chromatography , physics , astronomy
Long‐chain unsaturated fatty acids (UFA) can easily be converted on a microgram scale to the corresponding 2‐alkenyl‐4,4‐dimethyloxazolines by condensation with 2‐amino‐2‐methylpropanol (AMP). These modified molecules with a ‘hidden’ carboxyl group have been proved to be a class of useful derivatives for gas chromatography/mass spectrometry (GC/MS) of UFA mixtures. While possessing very good GC characteristics, the title compounds show regular, well‐recognizable diagnostic ion peaks of the double bond position in the chain. Detailed description of the method as well as electron impact (E1) mass spectra of derivatives resulting from mono‐, di and polyenoic (maximally containing six double bonds) acids are presented.