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Collisional spectroscopy as a screening procedure for the determination of 2‐(2‐furoyl)‐4(5)‐(2‐furanyl)‐1H‐imidazole from acid hydrolysis of B‐poly(L‐Lysine) and B‐albumin
Author(s) -
Pelli Beatrice,
Sturaro Alberto,
Traldi Pietro,
Lapolla Annunziata,
Poli Tiziana,
Fedele Domenico,
Crepaldi Gaetano
Publication year - 1988
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200150103
Subject(s) - imidazole , chemistry , derivatization , chromatography , acid hydrolysis , lysine , hydrolysis , mass spectrometry , spectroscopy , albumin , nuclear magnetic resonance spectroscopy , organic chemistry , amino acid , biochemistry , physics , quantum mechanics
The direct determination of 2‐(2‐furoyl)‐4(5)‐(2‐furanyl)‐1 H ‐imidazole (FFI), present in the acid hydrolysis products of B‐poly( L ‐lysine) and B‐albumin and which appears to be a key intermediate in the physicochemical changes occurring during the incubation of protein with glucose, has been carried out by collisional spectroscopy, using a commercial double‐focusing, reverse‐geometry mass spectrometer and without any sample derivatization and chromatographic separation procedures.