Picogram level determination of fluphenazine in human plasma by automated gas chromatography/mass selective detection | Zendy

Jemal Mohammed | Zendy; Ivashkiv Eugene | Zendy; Both Douglas | Zendy; Koski Richard | Zendy; Cohen Allen I. | Zendy

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Picogram level determination of fluphenazine in human plasma by automated gas chromatography/mass selective detection

Author(s) -

Jemal Mohammed,

Ivashkiv Eugene,

Both Douglas,

Koski Richard,

Cohen Allen I.

Publication year - 1987

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200141202

Subject(s) - chromatography , detection limit , fluphenazine , chemistry , gas chromatography , human plasma , plasma , physics , medicine , quantum mechanics , haloperidol , dopamine

An automated capillary column gas chromatography electron‐impact mass selective detection method has been developed for the determination of a major tranquilizing agent, fluphenazine. Using a new purification method and incorporating a deuterated internal reference, a limit of quantitation of 50 pg per ml of plasma was obtained.

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