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Picogram level determination of fluphenazine in human plasma by automated gas chromatography/mass selective detection
Author(s) -
Jemal Mohammed,
Ivashkiv Eugene,
Both Douglas,
Koski Richard,
Cohen Allen I.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200141202
Subject(s) - chromatography , detection limit , fluphenazine , chemistry , gas chromatography , human plasma , plasma , physics , medicine , quantum mechanics , haloperidol , dopamine
An automated capillary column gas chromatography electron‐impact mass selective detection method has been developed for the determination of a major tranquilizing agent, fluphenazine. Using a new purification method and incorporating a deuterated internal reference, a limit of quantitation of 50 pg per ml of plasma was obtained.