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Gas chromatographic/mass spectrometric studies of the urinary metabolites of male rats given indan
Author(s) -
Yu Kyung O.,
Olson Carl T.,
Ferry Michelle J.,
Serve M. P.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200141114
Subject(s) - decalin , urinary system , chemistry , chromatography , gas chromatography , kidney , medicine , diol , endocrinology , organic chemistry , catalysis
The identified urinary metabolites of male rats exposed to indan are: 1‐ and 2‐indanone; 1‐, 2‐ and 5‐indanol; 2‐and 3‐hydroxyl‐1‐indanone; and cis ‐ and trans ‐indan‐1,2‐diol. Indan causes kidney damage in male rats in a manner similar to the cyclic hydrocarbons cis ‐ and trans ‐decalin and JP‐10. Lesions produced by indan occur only in male rats and not in female or control rats.