Gas chromatographic/mass spectrometric studies of the urinary metabolites of male rats given indan | Zendy

Yu Kyung O. | Zendy; Olson Carl T. | Zendy; Ferry Michelle J. | Zendy; Serve M. P. | Zendy

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Gas chromatographic/mass spectrometric studies of the urinary metabolites of male rats given indan

Author(s) -

Yu Kyung O.,

Olson Carl T.,

Ferry Michelle J.,

Serve M. P.

Publication year - 1987

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200141114

Subject(s) - decalin , urinary system , chemistry , chromatography , gas chromatography , kidney , medicine , diol , endocrinology , organic chemistry , catalysis

The identified urinary metabolites of male rats exposed to indan are: 1‐ and 2‐indanone; 1‐, 2‐ and 5‐indanol; 2‐and 3‐hydroxyl‐1‐indanone; and cis ‐ and trans ‐indan‐1,2‐diol. Indan causes kidney damage in male rats in a manner similar to the cyclic hydrocarbons cis ‐ and trans ‐decalin and JP‐10. Lesions produced by indan occur only in male rats and not in female or control rats.

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