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Identification of urinary metabolites in rats exposed to the nephrotoxic agent 2,3,4‐trimethylpentane
Author(s) -
Yu Kyung O.,
Olson Carl T.,
Hobson David W.,
Serve M. P.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200141112
Subject(s) - nephrotoxicity , chemistry , nephropathy , urinary system , kidney , hydrocarbon , endocrinology , medicine , biochemistry , pharmacology , chromatography , toxicity , biology , organic chemistry , diabetes mellitus
Branched‐chain hydrocarbon‐induced nephropathy in male rats was examined using 2,3,4‐trimethylpentane. Lesions are elected only in male rats, not in females or in controls. Mechanisms of nephropathy may be the interaction of metabolites with the male rat‐specific protein alpha 2u globulin. The identified urinary metabolites of 2,3,4‐trimethylpentane in male rats given the hydrocarbon by gavage are 2,3,4‐trimethyl‐1‐pentanol, 2,3,4‐trimethyl‐2‐pentanol and 2,3,4‐trimethyl‐1‐pentanoic acid. Of the C 8 ‐isomers, 2,3,4‐trimethylpentane dosing leads to the highest incidence of kidney damage in male rats.