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Identification of new steroids in patients with 17α‐hydroxylase deficiency by capillary gas chromatography/mass spectrometry
Author(s) -
Blau N.,
Zachmann M.,
Kempken B.,
Staudenmann W.,
Möhr E.,
Curtius H.Ch.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200141111
Subject(s) - chromatography , mass spectrometry , capillary gas chromatography , chemistry , gas chromatography , gas chromatography–mass spectrometry , capillary action , identification (biology) , materials science , biology , botany , composite material
Urines of two children with 17α‐hydroxylase deficiency contained a number of 5‐pregnane‐ and pregnenediols, ‐triols and ‐tetrols with a hydroxy or oxo group in position 11 of the steroid ring. They are formed mainly from progesterone via 11‐hydroxyprogesterone, pregnanolone and corticosterone, respectively, or from pregnenolone. Three metabolites not previously described, 16‐hydroxypregnenolone, 6,21‐dihydroxypregnanediol and 6‐hydroxytetrahydrocorticosterone, were identified.