Premium
Selected ion monitoring analysis of CP‐55,940, a cannabinoid derived analgetic agent
Author(s) -
Fouda Hassan G.,
Lukaszewicz Joanne,
Luther Elbridge W.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200141104
Subject(s) - chromatography , selected ion monitoring , mass spectrometry , chemistry , gas chromatography , imidazole , extraction (chemistry) , opiate , capillary action , ion , gas chromatography–mass spectrometry , derivative (finance) , materials science , stereochemistry , organic chemistry , receptor , biochemistry , financial economics , economics , composite material
Abstract A method is described for the quantification in plasma of CP‐55,940, a new non‐opiate oral analgetic agent, using capillary gas chromatography/mass spectrometry. After extraction, derivation of the drug and a structural analog internal standard is carried out with trifluoracetyl imidazole. The derivative exhibited excellent gas chrornatographic properties. Electron impact yielded an abundant high mass ion whose monitoring permitted the sensitive and specific determination of CP‐55,940 down to 0.5 ng ml −1 .