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Improvement in sensitivity of fast atom bombardment mass spectrometry of amino acids by di‐isopropylphosphorylation
Author(s) -
Chai WenGang,
Yan Lin,
Wang GuangHui,
Liang XiYun,
Zhao YuFen,
Ji GaiJiao
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200140706
Subject(s) - derivatization , fast atom bombardment , mass spectrometry , chemistry , chromatography , amino acid , ion , glycerol , atom (system on chip) , sensitivity (control systems) , matrix (chemical analysis) , analytical chemistry (journal) , organic chemistry , biochemistry , electronic engineering , computer science , engineering , embedded system
Positive ion fast atom bombardment mass spectrometric sensitivities of seven amino acids and the corresponding di‐isopropylphosphorylated derivatives were carefully compared. Results showed that an improvement in sensitivity by factors of 4–29, mostly above 10, were achieved after the derivatization. The chemical noise derived from glycerol matrix was also greatly reduced by this derivatization.