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Field desorption tandem mass spectrometry of anthracycline antibiotics, cosmomycin A, B, A′, B′, C and D
Author(s) -
Hirayama Kazuo,
Akashi Satoko,
Ando Toshihiko,
Horino Issei,
Etoh Yuzuru,
Morioka Hajumu,
Shibai Hiroshiro,
Murai Asao
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200140703
Subject(s) - mass spectrometry , chemistry , collision induced dissociation , tandem mass spectrometry , mass spectrum , analytical chemistry (journal) , field desorption , dissociation (chemistry) , protonation , desorption , ion , chromatography , organic chemistry , ionization , adsorption
Abstract Field desorption mass spectrometry was applied to a series of underivatized anthracycline, cosmomycins, to obtain fragment ions which were mass analysed using the linked scan technique without using collision activated dissociation. The daughter spectra of the various protonated compounds contain sugar sequence information which is in the mass spectra. The mass spectrometric data make it clear that field desorption tandem mass spectrometry can become a valuable additional technique for the structural analysis of anthracyclines.