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Hydrolysis of 1,1 ˙ ,1″‐phosphinothioylidinetrisaziridine (thiotepa) in aqueous solution
Author(s) -
Pyatigorskaya Tatyana L.,
Zhilkova Olga Yu.,
Shelkovsky Vadim S.,
Arkhangelova Natalya M.,
Grizodub Alexander I.,
Sukhodub Leonid F.
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200140402
Subject(s) - chemistry , thiotepa , aqueous solution , hydrolysis , titration , potentiometric titration , chloride , salt (chemistry) , sodium , inorganic chemistry , chromatography , organic chemistry , ion , medicine , surgery , chemotherapy , cyclophosphamide
Abstract The behaviour of 1,1 ˙ ,1″‐phosphinothioylidinetrisaziridine (thiotepa) in water and aqueous salt solution of various acidity was studied by field ionization mass spectrometry (FI‐MS), TLC and potentiometric titration. The rate of thiotepa hydrolysis increased with increasing thiotepa, or sodium chloride concentration, and with decreasing pH. As hydrolysis products of thiotepa, mono‐ and dichloro derivatives formed in neutral, salt‐containing and acidic solution, tepa, and products formed by PN bond cleavage and release of aziridine have been identified.