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Redox reactions occurring during secondary ion mass spectrometry of some heteroanthracycline antitumor antibiotic precursors
Author(s) -
Main Dennis E.,
Ens Werner,
Beavis Ronald,
Schueler Bruno,
Standing Kenneth G.,
Westmore John B.,
Wong ChiuMing
Publication year - 1987
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200140207
Subject(s) - chemistry , mass spectrum , ion , mass spectrometry , protonation , polyatomic ion , redox , ionization , alkali metal , proton , fast atom bombardment , secondary ion mass spectrometry , spectral line , molecule , electron ionization , analytical chemistry (journal) , inorganic chemistry , organic chemistry , chromatography , physics , quantum mechanics , astronomy
Positive and negative secondary ion mass spectra of the title compounds were produced by bombardment of solid deposits by 13 and 23 KeV cesium ions, respectively, and analyzed with a time‐of‐flight mass spectrometer. In addition to familiar protonation and alkali (mainly sodium) ion addition processes observed in the positive ion spectra and proton abstractions in the negative ion spectra (which enable determination of molecular weight) there is evidence from both spectral modes for oxidation‐reduction processes in which species such as [M – H] + , [M – H + Na] +. and [M + 1] − are formed. It is argued that these may be formed rapidly from pre‐associated molecules during bombardment/ionization rather than as a result of radiation damage. Sodium ion addition is apparently facilitated by the presence of electron pair donor groups, especially if chelation is possible.