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Analysis of kava resin by gas chromatography and electron impact and methane negative ion chemical ionization mass spectrometry. New trace constituents of kava resin
Author(s) -
Duffield A. M.,
Lidgard R. O.
Publication year - 1986
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200131107
Subject(s) - kava , chemistry , electron ionization , chemical ionization , mass spectrometry , mass spectrum , methane , polyatomic ion , gas chromatography , ion , substituent , gas chromatography–mass spectrometry , ionization , analytical chemistry (journal) , chromatography , organic chemistry , medicine , pharmacology
Electron impact (EI) and methane negative ion chemical ionization (NICI) gas chromatographic/mass spectrometric analyses of kava resin, derived from commercial Piper methysticum , are described. The resulting mass spectra are correlated with the known major and trace constituents of this resin. Several of the kava lactones (kawain, methysticin, desmethoxyyangonin and yangonin) produced abundant molecular anions when analysed by methane NICI mass spectrometry, in contrast to their 7,8‐dihydro analogues which ionized with poor efficiency to yield weak [M − H] − anions. Deuterium labelling established that the origin of the [M − CH 3 ] − anion in the methane NICI mass spectrum of yangonin resulted from the elimination of a methyl radical from the 4‐methoxyl substituent. As a result of the present study, an additional four trace components of kava have been identified.