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Thermospray liquid chromatography/mass spectrometry of ether phosphocholines
Author(s) -
Mallet A. I.,
Rollins K.
Publication year - 1986
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200131005
Subject(s) - thermospray , chromatography , mass spectrometry , chemistry , ether , liquid chromatography–mass spectrometry , phosphocholine , phospholipid , tandem mass spectrometry , organic chemistry , biochemistry , selected reaction monitoring , membrane , phosphatidylcholine
A preliminary investigation into the practicability of using thermospray liquid chromatography/mass spectrometry for the analysis of the ether phosphocholine, platelet activating factor, is described. Using a deuterated internal standard, calibration curves for both the hexadecyl and the octadecyl forms of this substance have been obtained and, from these, the amounts and nature of platelet activating factor in human psoriatic skin have been determined.