Preparation of  18 O‐labelled standards of hydroxy‐eicosatetraenoic acids and thromboxanes for quantitative measurement by gas chromatography/mass spectrometry | Zendy

Leis H. J. | Zendy; Malle E. | Zendy; Moser R. | Zendy; Nimpf J. | Zendy; Kostner G. M. | Zendy; Esterbauer H. | Zendy; Gleispach H. | Zendy

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Preparation of 18 O‐labelled standards of hydroxy‐eicosatetraenoic acids and thromboxanes for quantitative measurement by gas chromatography/mass spectrometry

Author(s) -

Leis H. J.,

Malle E.,

Moser R.,

Nimpf J.,

Kostner G. M.,

Esterbauer H.,

Gleispach H.

Publication year - 1986

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200130906

Subject(s) - chemistry , thromboxanes , mass spectrometry , chromatography , gas chromatography , gas chromatography–mass spectrometry , chemical ionization , hydrolysis , derivatization , electron ionization , organic chemistry , ion , ionization , arachidonic acid , enzyme

A study on the extent of 18 O incorporation into various hydroxy‐eicosatetraenoic acids, thromboxane B 2 and 2,3‐dinor‐thromboxane B 2 by base‐catalysed hydrolysis of their methyl ester derivatives is presented. The amount as well as the position of the inbuilt 18 O atoms were determined by gas chromatography/mass spectrometry, utilizing electron impact and positive and negative ion chemical ionization.

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