Determination of 5α‐androstane‐3α, 17β‐diol and 5α‐androstane‐3β, 17β‐diol in human plasma by selected ion monitoring | Zendy

Jacolot F. | Zendy; Picart D. | Zendy; Berthou F. | Zendy; Floch H. H. | Zendy

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Determination of 5α‐androstane‐3α, 17β‐diol and 5α‐androstane‐3β, 17β‐diol in human plasma by selected ion monitoring

Author(s) -

Jacolot F.,

Picart D.,

Berthou F.,

Floch H. H.

Publication year - 1986

Publication title -

biomedical and environmental mass spectrometry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.475

H-Index - 121

eISSN - 1096-9888

pISSN - 0887-6134

DOI - 10.1002/bms.1200130802

Subject(s) - androstane , diol , chromatography , human plasma , chemistry , stereochemistry , organic chemistry

5α‐Androstane‐3α, 17β‐diol (3α‐diol) and 5α‐androstane‐3β, 17β‐diol (3β‐diol) were measured in human peripheral plasma by gas chromatography‐selected ion monitoring as their t ‐butyl dimethylsilyl ethers. The purification of the plasma extract involved a Sep‐Pak® C 18 cartridge and high‐performance liquid chromatography. The concentrations (mean ± SD) of the two diols in four normal males are: 213 ± 111 pg/ml for the 3α‐diol and 246 ± 133 pg/ml for the 3β‐diol.

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