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Mass spectrometric characterization of halo‐sugar nucleosides
Author(s) -
Alder L.,
Donau R.,
Stoesser R.,
Cech D.
Publication year - 1986
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200130503
Subject(s) - deoxyribonucleosides , chemistry , halogen , mass spectrometry , evaporation , mass spectrum , characterization (materials science) , ion , halo , organic chemistry , analytical chemistry (journal) , computational chemistry , chromatography , nanotechnology , materials science , alkyl , physics , thermodynamics , enzyme , quantum mechanics , galaxy
The fragmentations of 2′‐, 3′‐ and 5′‐halogenated deoxyribonucleosides were studied using low‐resolution mass spectrometry and deuteration experiments. The major reaction pathways provide ions which allow detection of halogen introduction and simple differentiation between the 3′‐ and 5′‐derivatives with respect to the 2′‐derivatives. Additionally, it has been shown that the 2′‐derivatives from 2,2′‐anhydrouridine during the process of evaporation, thus affecting the spectra obtained.