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Nucleic acid base complexes with thiotepa as revealed by field ionization mass spectrometry
Author(s) -
Sukhodub L. F.,
Shelkovsky V. S.,
Kosevich M. V.,
Pyatigorskaya T. L.,
Zhilkova O. Yu.
Publication year - 1986
Publication title -
biomedical and environmental mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 0887-6134
DOI - 10.1002/bms.1200130403
Subject(s) - thiotepa , chemistry , nucleic acid , mass spectrometry , aqueous solution , ionization , chromatography , combinatorial chemistry , biochemistry , organic chemistry , ion , biology , genetics , chemotherapy , cyclophosphamide
The interaction of nucleic acid bases with the alkylating antitumour drug thiotepa has been studied by field ionization mass spectrometry. The possibility of interaction between all four DNA bases and thiotepa in neutral aqueous solutions was demonstrated. The analysis of the data for different methylated bases made it possible to elucidate some sites of alkylation—N(1)(Cyt), N(3)(Thy), N(9)(Ade)—which are compared with data on other alkylating agents available from the literature.